Preparation and in vivo evaluation of a gel-based nasal delivery system for risperidone

Acta Pharmaceutica

Gu Fugen¹  Meng Gendalai²  Wu Chunzhi³  Wang Yi³  Ma Weina⁴ 

[1] Department of Pharmaceutics Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050 , China;Department of Pharmaceutics Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050 China;Department of Pharmaceutics Affiliated Hospital, Inner Mongolia Medical University, Hohhot 010050, China;School of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China;

关键词: risperidone;    nasal gel;    formulation;    pharmacokinetics;    bioavailability;    ciliotoxicity;   

DOI  :  10.1515/acph-2016-0047

来源: DOAJ

【 摘 要 】

The aim of this study was to prepare a nasal gel of risperidone and to investigate the pharmacokinetics and relative bioavailability of the drug in rats. Compared with oral dosing, the risperidone nasal gel exhibited very fast absorption and high bioavailability. Maximal plasma concentration (cmax) and the time to reach cmax (tmax) were 15.2 μg mL-1 and 5 min for the nasal gel, 3.6 μg mL-1 and 30 min for the oral drug suspension, respectively. Pharmacokinetic parameters such as tmax′, cmax and AUC of oral and nasal routes were significantly different (p < 0.01). Relative bioavailability of the drug nasal preparation to the oral suspension was up to 1600.0 %. Further, the in vitro effect of the risperidone nasal gel on nasal mucociliary movement was also investigated using a toad palate model. The risperidone nasal formulation showed mild ciliotoxicity, but the adverse effect was temporary and reversible.

【 授权许可】

Unknown