Understanding the Unique Microenvironment in the Aging Liver

Frontiers in Medicine

Jianzhou Li¹  Yalei Zhao¹  Ya Yang²  Qian Li² 

[1] Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China;State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, College of Medicine, The First Affiliated Hospital, Zhejiang University, Hangzhou, China;

关键词: aging;    microenvironment;    regeneration;    hepatic cells;    extracellular matrix;   

DOI  :  10.3389/fmed.2022.842024

来源: DOAJ

【 摘 要 】

In the past decades, many studies have focused on aging because of our pursuit of longevity. With lifespans extended, the regenerative capacity of the liver gradually declines due to the existence of aging. This is partially due to the unique microenvironment in the aged liver, which affects a series of physiological processes. In this review, we summarize the related researches in the last decade and try to highlight the aging-related alterations in the aged liver.

【 授权许可】

Unknown