Role and prospects of regenerative biomaterials in the repair of spinal cord injury

Neural Regeneration Research

关键词: nerve regeneration;    spinal cord injury;    regenerative biomaterials;    scaffolds;    tissue engineering;    regeneration;    transplantation;    combination;    functional recovery;    repair strategy;    microenvironment;    neural regeneration;   

DOI  :  10.4103/1673-5374.253512

来源: DOAJ

【 摘 要 】

Axonal junction defects and an inhibitory environment after spinal cord injury seriously hinder the regeneration of damaged tissues and neuronal functions. At the site of spinal cord injury, regenerative biomaterials can fill cavities, deliver curative drugs, and provide adsorption sites for transplanted or host cells. Some regenerative biomaterials can also inhibit apoptosis, inflammation and glial scar formation, or further promote neurogenesis, axonal growth and angiogenesis. This review summarized a variety of biomaterial scaffolds made of natural, synthetic, and combined materials applied to spinal cord injury repair. Although these biomaterial scaffolds have shown a certain therapeutic effect in spinal cord injury repair, there are still many problems to be resolved, such as product standards and material safety and effectiveness.

【 授权许可】

Unknown