Late‐onset behavioral variant of frontotemporal lobar degeneration versus Alzheimer's disease: Interest of cerebrospinal fluid biomarker ratios

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Sylvain Lehmann¹  Audrey Gabelle²  Jacques Touchon²  Patrice Douillet²  Claudine Berr²  Cecilia Marelli²  Laure‐Anne Gutierrez²  Delphine De Verbizier³  Celine Charroud⁴  Nicolas Menjot de Champfleur⁵ 

[1] CHRU de MontpellierUniversité de Montpellier, Institute of Regenerative Medicine and Bio‐therapy (IRMB)INSERM U1183, CCBHM, Laboratoire de Biochimie Protéomique CliniqueMontpellierFrance;Department of Neurology and Memory Research and Resources CenterGui de Chauliac University HospitalMontpellierFrance;Department of Nuclear MedicineGui de Chauliac University HospitalMontpellierFrance;INSERM U 1061—Neuropsychiatry: Epidemiological and Clinical ResearchMontpellierFrance;Institut d'Imagerie Fonctionnelle Humaine, I2FH, Gui de Chauliac University HospitalMontpellierFrance;

关键词: Alzheimer's disease;    Frontotemporal lobar degeneration;    Late‐onset frontotemporal lobar degeneration;    Cerebrospinal fluid;    Biomarkers;    Differential diagnosis;   

DOI  :  10.1016/j.dadm.2015.06.004

来源: DOAJ

【 摘 要 】

Abstract Introduction Cerebrospinal fluid (CSF) biomarker ratios were never evaluated in late‐onset (>65 years) behavioral variant of frontotemporal lobar degeneration (bvFTLD) versus Alzheimer's disease (AD). Methods A retrospective monocentric study on 44 clinically suspected amnestic AD or bvFTLD patients with onset after 65 years and available CSF and clinical data. Results The final clinical diagnosis was AD (n = 28; 64%), late‐onset bvFTLD (n = 14; 32%), and others (n = 2; 4%). Applying the CSF cutoff total‐tau/Aβ1–42 of 1.06, all the bvFTLD were in the FTLD range (<1.06, bvFTLD/FTLD), whereas the AD patients were either in the AD (>1.06, AD/AD) or in the FTLD range (<1.06, AD/FTLD); CSF biomarkers were significantly different in these three groups, but not neuroradiological features or presence of episodic memory deficit. Discussion Late‐onset bvFTLD is underdiagnosed. The available CSF biomarker ratio cutoff need further improvement and overestimated late‐onset bvFTLD but could potentially differentiate it from AD, notably in case of conflicting results.

【 授权许可】

Unknown