Solving neurodegeneration: common mechanisms and strategies for new treatments

Molecular Neurodegeneration

Preeti Subramanian¹  Diane E. Bovenkamp¹  Sharyn Rossi¹  M. Valeria Canto-Soler²  Anna La Torre³  Karthik Shekhar⁴  Albert A. Davis⁵  Guojun Bu⁶  Adriana Di Polo⁷  Larry I. Benowitz⁸  David J. Calkins⁹  Lauren K. Wareham⁹  Xin Duan^1,10  Cheryl Wellington^1,11  David C. Chan^1,12  Zhigang He^1,13  Thomas Brunner^1,14  John G. Flanagan^1,15  Sally Temple^1,16  Shane A. Liddelow^1,17  Jeffrey L. Goldberg^1,18 

[1] BrightFocus Foundation;CellSight Ocular Stem Cell and Regeneration Research Program, Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado;Department of Cell Biology and Human Anatomy, University of California Davis;Department of Chemical and Biomolecular Engineering and Helen Wills Neuroscience Institute, University of California Berkeley;Department of Neurology, Washington University in St. Louis;Department of Neuroscience, Mayo Clinic;Department of Neuroscience, University of Montreal;Department of Neurosurgery and F.M. Kirby Neurobiology Center, Boston Children’s Hospital, Harvard Medical School;Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center;Department of Ophthalmology, University of California San Francisco;Department of Pathology and Laboratory Medicine, University of British Columbia;Division of Biology and Biological Engineering, California Institute of Technology;F.M. Kirby Neurobiology Center, Boston Children’s Hospital;Glaucoma Research Foundation;Herbert Wertheim School of Optometry and Vision Science, University of California Berkeley;Neural Stem Cell Institute;Neuroscience Institute, NYU Grossman School of Medicine;Spencer Center for Vision Research, Byers Eye Institute, Stanford University;

关键词: Neurodegeneration;    Alzheimer’s Disease;    Glaucoma;    Parkinson’s Disease;    Huntington’s Disease;    Genetics;   

DOI  :  10.1186/s13024-022-00524-0

来源: DOAJ

【 摘 要 】

Abstract Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss emerging treatments, in April, 2021, Glaucoma Research Foundation, BrightFocus Foundation, and the Melza M. and Frank Theodore Barr Foundation collaborated to bring together key opinion leaders and experts in the field of neurodegenerative disease for a virtual meeting titled “Solving Neurodegeneration”. This “think-tank” style meeting focused on uncovering common mechanistic roots of neurodegenerative disease and promising targets for new treatments, catalyzed by the goal of finding new treatments for glaucoma, the world’s leading cause of irreversible blindness and the common interest of the three hosting foundations. Glaucoma, which causes vision loss through degeneration of the optic nerve, likely shares early cellular and molecular events with other neurodegenerative diseases of the central nervous system. Here we discuss major areas of mechanistic overlap between neurodegenerative diseases of the central nervous system: neuroinflammation, bioenergetics and metabolism, genetic contributions, and neurovascular interactions. We summarize important discussion points with emphasis on the research areas that are most innovative and promising in the treatment of neurodegeneration yet require further development. The research that is highlighted provides unique opportunities for collaboration that will lead to efforts in preventing neurodegeneration and ultimately vision loss.

【 授权许可】

Unknown