Daily intake of β-cryptoxanthin prevents bone loss by preferential disturbance of osteoclastic activation in ovariectomized mice

Journal of Pharmacological Sciences

Minoru Sugiura¹  Yukio Yoneda²  Yuki Onishi²  Maika Okamoto²  Takashi Iezaki²  Eiichi Hinoi²  Kakeru Ozaki²  Kazuya Fukasawa² 

[1] Citrus Research Division, NARO Institute of Fruit Tree Science, National Agriculture and Food Research Organization, Shimizu, Shizuoka, Japan;Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, Ishikawa, Japan;

关键词: Osteoclast;    Osteoporosis;    Osteoblast;   

DOI  :  10.1016/j.jphs.2015.08.003

来源: DOAJ

【 摘 要 】

Although β-cryptoxanthin, a xanthophyll carotenoid, has been shown to exert an anabolic effect on bone calcification, little attention has been paid thus far to the precise mechanism of bone remodeling. Daily oral administration of β-cryptoxanthin significantly inhibited osteoclastic activation as well as reduction of bone volume in ovariectomized mice. In vitro studies revealed that β-cryptoxanthin inhibited differentiation and maturation of osteoclasts by repression of the nuclear factor-κB-dependent transcriptional pathway. Our results suggest that supplementation with β-cryptoxanthin would be beneficial for prophylaxis and for therapy of metabolic bone diseases associated with abnormal osteoclast activation.

【 授权许可】

Unknown