Bacteriophages in the control of pathogenic vibrios

Electronic Journal of Biotechnology

Diliana Pérez-Reytor¹  Katherine García¹  Nicolás Plaza¹  Gastón Higuera²  Roberto Bastías³  Daniel Castillo⁴ 

[1] Centro de Investigación Biomédica, Facultad de Ciencias de la Salud, Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, San Miguel, Chile;Instituto de Nutrición y Tecnología de los Alimentos, INTA, Universidad de Chile, Macul, Santiago, Chile;Laboratorio de Microbiología, Instituto de Biología, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile;Marine Biological Section, University of Copenhagen, Strandpromenaden 5, DK-3000 Helsingør, Denmark;

关键词: Antibiotic;    Cholera;    Gram-negative bacteria;    Phage therapy;    Vibrio anguillarum;    Vibrio cholerae;    Vibrio harveyi;    Vibrio parahaemolyticus;    Vibrio;    Virulence;   

DOI  :  10.1016/j.ejbt.2017.10.012

来源: DOAJ

【 摘 要 】

Vibrios are common inhabitants of marine and estuarine environments. Some of them can be pathogenic to humans and/or marine animals using a broad repertory of virulence factors. Lately, several reports have indicated that the incidence of Vibrio infections in humans is rising and also in animals constitute a continuing threat for aquaculture. Moreover, the continuous use of antibiotics has been accompanied by an emergence of antibiotic resistance in Vibrio species, implying a necessity for efficient treatments. One promising alternative that emerges is the use of lytic bacteriophages; however, there are some drawbacks that should be overcome to make phage therapy a widely accepted method. In this work, we discuss about the major pathogenic Vibrio species and the progress, benefits and disadvantages that have been detected during the experimental use of bacteriophages to their control.

【 授权许可】

Unknown