Surgical management of submacular hemorrhage due to n-AMD: a comparison of three surgical methods

International Journal of Retina and Vitreous

Spyridon Dimopoulos¹  Karl Ulrich Bartz-Schmidt¹  Philipp Schindler²  Martin S. Spitzer²  Christos Skevas²  Toam Katz²  Carsten Grohmann² 

[1] Department of Ophthalmology, Eberhard Karls University Medical Center;Department of Ophthalmology, University Medical Center Hamburg-Eppendorf (UKE);

关键词: Acute submacular hemorrhage (ASH);    Neovascular age related macular degeneration (n-AMD);    Choroidal neovascularization (CNV);    Vascular endothelial growth factor (VEGF);    Retinal pigment epithelium (RPE);    Central foveal thickness (CFT);   

DOI  :  10.1186/s40942-020-00228-x

来源: DOAJ

【 摘 要 】

Abstract Background To compare and assess the efficacy of three surgical methods for the treatment of acute submacular hemorrhage (ASH): pneumatic displacement with C2F6, in combination with intravitreal injection of bevacizumab and rtPA, pars plana vitrectomy (PPV) with intravitreal injection of gas (C2F6), bevacizumab and subretinal injection of recombinant tissue plasminogen activator (rtPA), pars plana vitrectomy (PPV) with intravitreal injection of gas (C2F6), bevacizumab and intravitreal injection of recombinant tissue plasminogen activator (rtPA). Methods The study included 85 patients with ASH. In the group without PPV (A), patients were treated with intravitreal injection of C2F6, bevacizumab and rtPA. In the second and third group, patients underwent a PPV, intravitreal injection of bevacizumab, pneumatic displacement with C2F6 and a subretinal (B) or intravitreal (C) injection of recombinant tissue plasminogen activator (rt PA). Results In group A, mean BCVA increased from preop logMAR 1.41 to 1.05, in group B from 1.46 to 1.28 and in group C from 1.63 to 1.33. In group A, CFT changed from 764 ± 340 μm at time point 0 to 246 ± 153 μm at time point 1, in group B from 987 ± 441 μm to 294 ± 166 μm and in group C from 642 ± 322 μm to 418 ± 364 μm. Patients had an average of 5 injections after surgery. Conclusion Our study demonstrates that the three methods are equally effective in improving the morphology and the BCVA of patients with ASH.

【 授权许可】

Unknown