Prodrug of epigallocatechin-3-gallate alleviates choroidal neovascularization via down-regulating HIF-1α/VEGF/VEGFR2 pathway and M1 type macrophage/microglia polarization

Biomedicine & Pharmacotherapy

Yang Guo¹  Laiqing Xie¹  Xun Xu²  Yuanyuan Tu³  Jingxia Du³  Ying Wang³  Manhui Zhu⁴  Shu Du⁵  Jiaowen Xu⁵  Yonghui Gu⁵  E. Song⁵  Qingliang Zhao⁶  Xiaodong Sun⁶ 

[1] Department of Ophthalmology, Shanghai First People’s Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China;Department of Ophthalmology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China;Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, Jiangsu, China;Department of Ophthalmology, Suzhou Municipal Hospital, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China;Department of Ophthalmology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China;Shanghai Key Laboratory of Ocular Fundus Disease, Shanghai, China;

关键词: Prodrug of epigallocatechin-3-gallate (pro-EGCG);    Age-related macular degeneration (AMD);    Choroidal neovascularization (CNV);    HIF-1α/VEGF/VEGFR2 pathway;    M1-type macrophages/microglia;   

DOI  :  

来源: DOAJ

【 摘 要 】

Age-related macular degeneration (AMD) is a leading cause of vision loss in the elderly and is attributed to choroidal neovascularization (CNV), which is a feature of wet AMD. The hypoxia-inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR2) pathway contributes to the pathogenesis of CNV. M1-type macrophages/microglia secrete interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α), facilitating the development of CNV. Epigallocatechin-3-gallate (EGCG) is a kind of polyphenol in green tea that exerts anti-inflammatory and antiangiogenic effects. In this study, a prodrug of EGCG (pro-EGCG) alleviated mouse laser-induced CNV leakage and reduced CNV area by down-regulating HIF-1α/VEGF/VEGFR2 pathway; M1-type macrophage/microglia polarization; as well as endothelial cell viability, proliferation, migration and tube formation, indicating a novel potential therapy for AMD.

【 授权许可】

Unknown