Effect of pregnancy and HIV infection on detection of latent TB infection by Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube assay among women living in a high TB and HIV burden setting

International Journal of Infectious Diseases

Aster Tsegaye¹  Girmay Desalegn²  Mahlet Birku³  Getachew Kassa⁴  Markos Abebe⁵ 

[1] Corresponding author at: Department of Medical Microbiology and Immunology, Mekelle University, P.O. Box: 1871, Mekelle, Ethiopia.;Department of Medical Laboratory Sciences, Addis Ababa University, Addis Ababa, Ethiopia;Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia;Department of Medical Microbiology and Immunology, Mekelle University, Mekelle, Ethiopia;Ethiopian Public Health Institute, Addis Ababa, Ethiopia;

关键词: Pregnancy;    HIV;    M. tuberculosis;    Detection rate;    Latent TB infection;    TST;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objective: To investigate the effect of pregnancy and Human immunodeficiency virus (HIV) infection on detection performances of tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube (QFTGIT) for the diagnosis of latent tuberculosis infection (LTBI) among women living in high TB and HIV endemic setting. Method: A cross-sectional study was conducted among women with and without pregnancy and HIV infection. Three-hundred twenty women were enrolled in this study and were diagnosed using TST and QFTGIT for the detection of LTBI. Results: Overall prevalence of LTBI among the enrolled women was 55.6%, 46.3% and 51.1% as determined by TST, QFTGIT and concordant TST/QFTGIT results, respectively. Our study revealed that pregnancy or HIV infection reduced the rate of detection of LTBI by TST and QFTGIT tests, with the utmost effect observed in HIV-positive pregnant women. Additionally, we observed that the concordance between TST and QFTGIT among women increased with the presence of pregnancy and/or HIV infection. A history of contact with TB patients was significantly associated with positivity of TST and QFTGIT. Conclusion: This study demonstrated that both pregnancy and HIV infection profoundly affected the detection performance of TST and QFTGIT, which may be associated with immunosuppression of anti-mycobacterial immunity in women with pregnancy and/or HIV infection.

【 授权许可】

Unknown