期刊论文详细信息
NeuroImage: Clinical
Cerebral amyloid angiopathy is associated with decreased functional brain connectivity
Jeroen van der Grond1  Marieke J.H. Wermer2  Gisela M. Terwindt3  M. Edip Gurol4  Steven M. Greenberg4  Sanneke van Rooden5  Mark A. van Buchem6  Serge A.R.B. Rombouts6  Jasmeer P. Chhatwal6  Nadieh Drenth6 
[1] Corresponding author at: Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2300 RC Leiden, The Netherlands.;Leiden Institute for Brain and Cognition, P.O. Box 9600, 2300 RC Leiden, The Netherlands;Leiden University, Institute of Psychology, P.O. Box 9555, 2300 RB Leiden, The Netherlands;Department of Neurology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands;Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA;Department of Radiology, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands;
关键词: Functional connectivity;    Resting state networks;    Cerebral amyloid angiopathy;    Functional magnetic resonance imaging;    Neuroimaging;   
DOI  :  
来源: DOAJ
【 摘 要 】

Cerebral amyloid angiopathy (CAA) is a major cause of intracerebral hemorrhage and neurological decline in the elderly. CAA results in focal brain lesions, but the influence on global brain functioning needs further investigation. Here we study functional brain connectivity in patients with Dutch type hereditary CAA using resting state functional MRI. Twenty-four DNA-proven Dutch CAA mutation carriers (11 presymptomatic, 13 symptomatic) and 29 age-matched control subjects were included. Using a set of standardized networks covering the entire cortex, we assessed both within- and between-network functional connectivity. We investigated group differences using general linear models corrected for age, sex and gray matter volume. First, all mutation carriers were contrasted against control subjects and subsequently presymptomatic- and symptomatic mutation carriers against control subjects separately, to assess in which stage of the disease differences could be found. All mutation carriers grouped together showed decreased connectivity in the medial and lateral visual networks, default mode network, executive control and bilateral frontoparietal networks. Symptomatic carriers showed diminished connectivity in all but one network, and between the left and right frontoparietal networks. Presymptomatic carriers also showed diminished connectivity, but only in the frontoparietal left network. In conclusion, global brain functioning is diminished in patients with CAA, predominantly in symptomatic CAA and can therefore be considered to be a late consequence of the disease.

【 授权许可】

Unknown   

  文献评价指标  
  下载次数:0次 浏览次数:0次