期刊论文详细信息
NEUROSCIENCE LETTERS 卷:485
Brain resting state is disrupted in chronic back pain patients
Article
Tagliazucchi, Enzo2  Balenzuela, Pablo2,3  Fraiman, Daniel3,4  Chialvo, Dante R.1,3,5 
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol, Los Angeles, CA 90095 USA
[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Fis, RA-1053 Buenos Aires, DF, Argentina
[3] Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina
[4] Univ San Andres, Dept Matemat & Ciencias, Buenos Aires, DF, Argentina
[5] Univ Nacl Rosario, Fac Ciencias Med, RA-2000 Rosario, Santa Fe, Argentina
关键词: Brain;    Default mode network;    Chronic pain;    fMRI;    Resting state networks;    Functional connectivity;   
DOI  :  10.1016/j.neulet.2010.08.053
来源: Elsevier
PDF
【 摘 要 】

Recent brain functional magnetic resonance imaging (fMRI) studies have shown that chronic back pain (CBP) alters brain dynamics beyond the feeling of pain. In particular, the response of the brain default mode network (DMN) during an attention task was found abnormal. In the present work similar alterations are demonstrated for spontaneous resting patterns of fMRI brain activity over a population of CBP patients (n = 12, 29-67 years old, mean = 51.2). Results show abnormal correlations of three out of four highly connected sites of the DMN with bilateral insular cortex and regions in the middle frontal gyrus (p < 0.05), in comparison with a control group of healthy subjects (n = 20, 21-60 years old, mean = 38.4). The alterations were confirmed by the calculation of triggered averages, which demonstrated increased coactivation of the DMN and the former regions. These findings demonstrate that CBP disrupts normal activity in the DMN even during the brain resting state, highlighting the impact of enduring pain over brain structure and function. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

【 授权许可】

Free   

【 预 览 】
附件列表
Files Size Format View
10_1016_j_neulet_2010_08_053.pdf 1223KB PDF download
  文献评价指标  
  下载次数:0次 浏览次数:0次