An Update of Nucleic Acids Aptamers Theranostic Integration with CRISPR/Cas Technology

Molecules

Hayley N. Templeton¹  Julietta A. Sheng¹  Mina Roueinfar¹  Ka Lok Hong² 

[1] Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA;Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy, Wilkes University, 84 W. South Street, Wilkes-Barre, PA 18766, USA;

关键词: CRISPR;    aptamer;    theranostic;    biosensing;    molecular recognition elements (MRE);   

DOI  :  10.3390/molecules27031114

来源: DOAJ

【 摘 要 】

The clustered regularly interspaced short palindromic repeat (CRISPR)/Cas system is best known for its role in genomic editing. It has also demonstrated great potential in nucleic acid biosensing. However, the specificity limitation in CRISPR/Cas has created a hurdle for its advancement. More recently, nucleic acid aptamers known for their high affinity and specificity properties for their targets have been integrated into CRISPR/Cas systems. This review article gives a brief overview of the aptamer and CRISPR/Cas technology and provides an updated summary and discussion on how the two distinctive nucleic acid technologies are being integrated into modern diagnostic and therapeutic applications

【 授权许可】

Unknown