Aptamer-assembled nanomaterials for fluorescent sensing and imaging

Nanophotonics

article

Danqing Lu¹  Lei He¹  Ge Zhang¹  Aiping Lv²  Ruowen Wang¹  Xiaobing Zhang¹  Weihong Tan¹ 

[1] Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Collaborative Innovation Center for Chemistry and Molecular Medicine, Hunan University;Institute for Advancing Translational Medicine in Bone and Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University;Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Health Cancer Center, University of Florida, United States of America

关键词: aptamer;    bioimaging;    biosensing;    cancer therapy;    disease diagnosis;    drug delivery;    nanomaterials;    self-assembly;   

DOI  :  10.1515/nanoph-2015-0145

学科分类：社会科学、人文和艺术（综合）

来源: De Gruyter

【 摘 要 】

Aptamers, which are selected in vitro by a technology known as the systematic evolution of ligands by exponential enrichment (SELEX), represent a crucial recognition element in molecular sensing. With advantages such as good biocompatibility, facile functionalization, and special optical and physical properties, various nanomaterials can protect aptamers from enzymatic degradation and nonspecific binding in living systems and thus provide a preeminent platform for biochemical applications. Coupling aptamers with various nanomaterials offers many opportunities for developing highly sensitive and selective sensing systems. Here, we focus on the recent applications of aptamer-assembled nanomaterials in fluorescent sensing and imaging. Different types of nanomaterials are examined along with their advantages and disadvantages. Finally, we look toward the future of aptamer-assembled nanomaterials.

【 授权许可】

CC BY