3D Printing of PLLA/Biomineral Composite Bone Tissue Engineering Scaffolds

Materials

Weilong Ye¹  Fangli Gang²  Wenting Wang²  Yi Xiao²  Chang Liu³  Xiaodan Sun⁴  Chunyang Ma⁵ 

[1] Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing 100050, China;Department of Biology, Xinzhou Teachers University, Xinzhou 034000, China;Department of Stomatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China;Key Laboratory of Advanced Materials of Ministry of Education, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China;Key Laboratory of Biomechanics and Mechanobiology, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China;

关键词: biominerals;    3D printing;    bone tissue engineering;   

DOI  :  10.3390/ma15124280

来源: DOAJ

【 摘 要 】

Tissue engineering is one of the most effective ways to treat bone defects in recent years. However, current highly active bone tissue engineering (BTE) scaffolds are mainly based on the addition of active biological components (such as growth factors) to promote bone repair. High cost, easy inactivation and complex regulatory requirements greatly limit their practical applications. In addition, conventional fabrication methods make it difficult to meet the needs of personalized customization for the macroscopic and internal structure of tissue engineering scaffolds. Herein, this paper proposes to select five natural biominerals (eggshell, pearl, turtle shell, degelatinated deer antler and cuttlebone) with widely available sources, low price and potential osteo-inductive activity as functional particles. Subsequently compounding them into L-polylactic acid (PLLA) biomaterial ink to further explore 3D printing processes of the composite scaffold, and reveal their potential as biomimetic 3D scaffolds for bone tissue repair. The research results of this project provide a new idea for the construction of a 3D scaffold with growth-factor-free biomimetic structure, personalized customization ability and osteo-inductive activity.

【 授权许可】

Unknown