Tantalum Nanoparticles Reinforced PCL Scaffolds Using Direct 3D Printing for Bone Tissue Engineering

Frontiers in Materials

Yihe Hu²  Xi He²  Pengfei Lei²  Hu Qian²  Ting Lei²  Wenbin Liu²  Zixuan Xiong³ 

[1] Department of Orthopedics, Xiangya Hospital of Central South University, Changsha, China;Hunan Engineering Research Center of Biomedical Metal and Ceramic Implants, Changsha, China;Xiangya School of Medicine, Central South University, Changsha, China;

关键词: polycarbonate(PCL);    tantalum;    bone tissue engineering;    osteogenesis;    3D printing;   

DOI  :  10.3389/fmats.2021.609779

来源: DOAJ

【 摘 要 】

Polycarbonate (PCL) has been widely used in tissue engineering, but its hydrophobicity and low biological activity limit its further promotion and application. By adding nanoparticles, the hydrophilicity and biological activity of PCL can be improved. In this study, different amounts of Ta (1–10%wt) were added to PCL, and then their mechanical and biological properties were studied in vitro. XRD found that 5%Ta-PCL has the highest crystallinity. At the same time, cell experiments CCK8, cell adhesion, osteogenic differentiation, and osteogenesis related gene expression showed that Ta can enhance the mechanical and biological properties of PCL, while 5% Ta-PCL showed the best mechanical and biological properties. This composite of tantalum and PCL could have a clinical potential for orthopedic implants.

【 授权许可】

Unknown