Abietane-Type Diterpenoids From Nepeta bracteata Benth. and Their Anti-Inflammatory Activity

Frontiers in Chemistry

Er-Lan Yang¹  Yong Hou¹  Zhao-Cui Sun¹  Xu-Dong Xu¹  Jun-Shan Yang¹  Guo-Xu Ma¹  Lin-Jun Zou¹  Hai-Feng Wu¹  Lei-Ling Shi²  Cong-Zhao Fan²  Hong-Wan Wei² 

[1] Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Peking, China;Xinjiang Institute of Chinese and Ethnic Medicine, Urumqi, China;

关键词: abietane-type diterpenoids;    ursane-type triterpenoid;    Nepeta bracteata Benth.;    anti-inflammatory;    drug candidates;   

DOI  :  10.3389/fchem.2022.944972

来源: DOAJ

【 摘 要 】

Terpenes possess a wide range of structural features and pharmaceutical activities and are promising for drug candidates. With the aim to find bioactive terpene molecules, eight new compounds were isolated from the medicinal plant Nepeta bracteata Benth., including seven new abietane-type diterpenoids (1–7), along with a new ursane-type triterpenoid(8). The structures of compounds 1–8 were elucidated through the detailed spectroscopic analyses of their 1D and 2D NMR and MS data, and the absolute configurations of compounds 1–7 were determined by comparing their experimental and calculated ECD spectra. Compound 1 was a novel degraded carbon diterpene with the disappearing of methyl signal at C-19, while compound 7 possessed a new norabietane-type diterpenoid carbon skeleton with the presence of five-membered lactone arising from ring rearrangement. The anti-inflammatory of all obtained isolates were evaluated on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and the results of anti-inflammatory activity screening showed that compared with the LPS model group, all compounds were significantly down-regulation the TNF-α inflammatory factor at the specific concentration, except for compound 6.

【 授权许可】

Unknown