Carbon Monoxide Controllable Targeted Gas Therapy for Synergistic Anti-inflammation

iScience

Yuhuan Sun¹  Xiaogang Qu²  Zhi Du²  Mengmeng Ma³  Jinsong Ren³  Chun Liu³ 

[1] University of Chinese Academy of Sciences, Beijing 100039, China;University of Science and Technology of China, Hefei, Anhui 230026, China;Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China;

关键词: Chemistry;    Biochemistry;    Nanotechnology;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Carbon monoxide (CO) plays an important role in the regulation of a variety of physiological processes and thus is regarded as a promising pharmaceutical agent. Nevertheless, therapeutic applications of CO are severely hampered by the difficulty of the delivery of controlled amounts of CO to biological targets. To address this deficiency, we present a spatiotemporally controllable CO-releasing platform (designated as Neu-MnO2/Fla) for synergistic anti-inflammation. With the assistance of neutrophil membrane coating, Neu-MnO2/Fla can target to inflammatory sites. Subsequently, excess H2O2 at the inflamed tissues can be decomposed into oxygen because of MnO2 as nanozymes possessing catalase (CAT) activity, which not only relieves oxidative stress but also achieves in situ rapid photo-induced CO release. The in vitro and in vivo results indicate our CO-releasing platform exhibits a strong synergistic anti-inflammatory effect. Our work will shed light on targeted CO release to avoid side effects of therapeutic applications of CO.

【 授权许可】

Unknown