Aqueous extract of Houttuynia cordata ameliorates aortic endothelial injury during hyperlipidemia via FoxO1 and p38 MAPK pathway

Journal of Functional Foods

Weijin Zang¹  Ke Cao²  Chuan Qin²  Jianshu Liu²  Weiqiang Lv²  Jing Gao²  Xuyun Liu²  Jing Liu²  Yan Wang²  Jiankang Liu³ 

[1] Center for Functional Food Engineering and Technology, Xi’an, China;Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China;Department of Pharmacology, School of Basic Medical Sciences, Xian Jiaotong University Health Science Center, Xi'an 710061, China;

关键词: Houttuynia cordata aqueous extract;    Hyperlipidemia;    Endothelial dysfunction;    Mitochondrial function;    FoxO1;    p38 MAPK;   

DOI  :  

来源: DOAJ

【 摘 要 】

Increasing evidence demonstrates that hyperlipidemia plays a causal role in the development of cardiovascular diseases (CVDs) due to endothelial dysfunction. Houttuynia cordata aqueous extract (HAE), using as both medicine and food, whose effect and mechanism were investigated in endothelial dysfunction. In vivo, it profoundly attenuated hyperlipidemia-induced accumulation of serum metabolites, which in turn contributed to alleviating morphologic and functional damage in vascular endothelium. Moreover, the decrease expression of FoxO1/PGC-1α and mitochondrial complexes in thoracic vessels were ameliorated by HAE administration. Through in vitro cultures, consistently, the results showed that HAE predominantly activated PGC-1α for mitochondrial biogenesis via enhancing FoxO1 expression. Additionally, silencing of FoxO1 remarkably abolished the ability of HAE to augment PGC-1α expression, implying the imperative role of FoxO1 during protection. Besides, the anti-inflammation was mainly mediated via p38 MAPK pathway. Briefly, our study demonstrated that HAE ameliorated hyperlipidemia-induced endothelial injury via upregulating FoxO1/PGC-1α and suppressing p38 MAPK.

【 授权许可】

Unknown