Prevalence of Nontuberculous Mycobacteria (NTM) in Iranian Clinical Specimens: Systematic Review and Meta-Analysis

Journal of Medical Bacteriology

Kiarash Ghazvini¹  Azad Khaledi²  Davoud Esmaeili³  Abbas Bahador⁴ 

[1] Antimicrobial Resistance Research Center, Avicenna Research Institute, Department of Microbiology and Virology, Faculty of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran.;Antimicrobial Resistance Research Center, Avicenna Research Institute, Department of Microbiology and Virology, Faculty of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran.;Applied Microbiology Research Center, and Microbiology Department, Baqiyatallah University of Medical Sciences, Tehran, Iran.;Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.;

关键词: Nontuberculous Mycobacteria;    Prevalence;    Iran;    Clinical Specimen;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Although, nontuberculous mycobacteria can cause disease in different organisms, they
usually are not reported in most countries because scientists in general consider them as non-pathogens.
But, increasing nontuberculous mycobacteria diseases occurrence has changed this belief. Nevertheless,
there is no meta-analysis review about prevalence of nontuberculous mycobacteria in Iran.
Methods: Any data about prevalence of nontuberculous mycobacteria in clinical specimens in Iran
were retrieved by searching data bases such as Pub Med, MEDLINE, and Iranian data bases. Then the
meta-analysis was performed by comprehensive meta-analysis software (CMA).
Results: The meta-analysis showed that the prevalence of nontuberculous mycobacteria in the clinical
specimens in Iran was 1.3%. In the studies that had sample size less than 300, and in studies conducted
after 2004, the prevalence was higher. Also, the prevalence of nontuberculous mycobacteria was higher
in the West of Iran. In this study, the most prevalent rapid-growing mycobacterium was Mycobacterium.
fortuitum and most prevalent slow-growing mycobacterium was M. simiae with the prevalence 44.2%
and 14.3%, respectively.
Conclusion: M. simiae is the most prevalent nontuberculous mycobacteria in the clinical specimens
in Iran. As this species of nontuberculous mycobacteria has similar clinical and radiological
manifestations with tuberculosis, it is often treated as tuberculosis. Unfortunately, M. simiae is resistant
against first-line anti-TB drugs resulting in treatment failure after using routine anti-TB medication.
Therefore, there is an urgent need for application of new diagnostic strategy for identification of
nontuberculous mycobacteria species.

【 授权许可】

Unknown