The Multiple Roles of Microrna-223 in RegulatingBone Metabolism

Molecules

Peifu Tang¹  Yong Xie¹  Lihai Zhang¹  Wei Ge²  Yanpan Gao² 

[1] Department of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China;National Key Laboratory of Medical Molecular Biology, Department of Immunology,Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China;

关键词: miR-223;    osteoclast;    osteoblast;    bone metabolism;   

DOI  :  10.3390/molecules201019433

来源: DOAJ

【 摘 要 】

Bone metabolism is a lifelong process for maintaining skeletal system homeostasis, which is regulated by bone-resorbing osteoclasts and bone-forming osteoblasts. Aberrant differentiation of osteoclasts and osteoblasts leads to imbalanced bone metabolism, resulting in ossification and osteolysis diseases. MicroRNAs (miRNAs) are pivotal factors in regulating bone metabolism via post-transcriptional inhibition of target genes. Recent studies have revealed that miR-223 exerts multiple effects on bone metabolism, especially in the processes of osteoclast and osteoblasts differentiation. In this review, we highlight the roles of miR-223 during the processes of osteoclast and osteoblast differentiation, as well as the potential clinical applications of miR-223 in bone metabolism disorders.

【 授权许可】

Unknown