The Role of XBP1 in bone metabolism

Frontiers in Endocrinology

Endocrinology

Junjun Jiao¹  Ning Ma¹  Wenhao Lv¹  Yu Fu¹  Tingrui Xu¹  Li Zhang¹  Youli Zheng²  Zheng Zhang³ 

[1] Hospital of Stomatology, Jilin University, Changchun, China;The School and Hospital of Stomatology, Tianjin Medical University, Tianjin, China;Tianjin Stomatological Hospital, School of Medicine, Nankai University, Tianjin, China;Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin, China;

关键词: XBP1;    osteoclast;    osteoblast;    immune microenvironment;    bone metabolism;   

DOI  :  10.3389/fendo.2023.1217579

 received in 2023-05-10, accepted in 2023-09-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

Bone is a dynamic organ that, once formed, undergoes a constant remodeling process that includes bone resorption and synthesis. Osteoclasts and osteoblasts are primarily responsible for controlling this process. X-box binding protein 1 (XBP1), a transcription factor, affects the metabolism of bones in various ways. In recent years, numerous studies have revealed that XBP1 plays a vital role in bone metabolism, including osteoclast and osteoblast development, as well as in regulating immune cell differentiation that affects the immune microenvironment of bone remodeling. In this review, we highlight the regulatory mechanisms of XBP1 on osteoclasts and osteoblasts, how XBP1 affects the immune microenvironment of bone remodeling by influencing the differentiation of immune cells, and predict the possible future research directions of XBP1 to provide new insights for the treatment of bone-related metabolic diseases.

【 授权许可】

Unknown   
Copyright © 2023 Lv, Zheng, Jiao, Fu, Xu, Zhang, Zhang and Ma