Molecules | |
The Multiple Roles of Microrna-223 in Regulating Bone Metabolism | |
Yong Xie1  Lihai Zhang1  Yanpan Gao2  Wei Ge2  Peifu Tang1  | |
[1] Department of Orthopedics, General Hospital of Chinese PLA, Beijing 100853, China; E-Mails:;National Key Laboratory of Medical Molecular Biology, Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing 100005, China; E-Mail: | |
关键词: miR-223; osteoclast; osteoblast; bone metabolism; | |
DOI : 10.3390/molecules201019433 | |
来源: mdpi | |
【 摘 要 】
Bone metabolism is a lifelong process for maintaining skeletal system homeostasis, which is regulated by bone-resorbing osteoclasts and bone-forming osteoblasts. Aberrant differentiation of osteoclasts and osteoblasts leads to imbalanced bone metabolism, resulting in ossification and osteolysis diseases. MicroRNAs (miRNAs) are pivotal factors in regulating bone metabolism via post-transcriptional inhibition of target genes. Recent studies have revealed that miR-223 exerts multiple effects on bone metabolism, especially in the processes of osteoclast and osteoblasts differentiation. In this review, we highlight the roles of miR-223 during the processes of osteoclast and osteoblast differentiation, as well as the potential clinical applications of miR-223 in bone metabolism disorders.
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190004494ZK.pdf | 759KB | download |