Syringaldehyde promoting intestinal motility with suppressing α-amylase hinders starch digestion in diabetic mice

Biomedicine & Pharmacotherapy

Ching-Feng Weng¹  Ting-Hsu Chen²  Wei-Hao Weng³  Lebin Weng⁴  Liyue Huang⁴  Qingyan Zheng⁴  Dong Lai⁵  Yaw-Syan Fu⁵ 

[1] Department of Anatomy, School of Basic Medical Science, Xiamen Medical College, Xiamen 361023, Fujian, China;Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan;Department of Pharmacy, China Medical University, Taichung 40402, Taiwan;Department of Physiology, School of Basic Medical Science, Xiamen Medical College, Xiamen 361023, Fujian, China;Medical Research Center, the Second Affiliated Hospital of Xiamen Medical College, Xiamen 361021, Fujian, China;

关键词: Syringaldehyde;    M2 receptor;    Acetylcholinesterase;    Intestinal contractility;    DPP4;    PPAR gamma;   

DOI  :  

来源: DOAJ

【 摘 要 】

The antihyperglycemic potential of syringaldehyde has been previously investigated; however, the underlying mechanism remains unclear. In this study, we performed a postprandial glucose test (in vivo) including oral glucose tolerance test (OGTT) and oral starch tolerance test (OSTT) in fructose-induced diabetic mice on a high-fat diet for mimicking type 2 diabetes to explore the hypoglycemic efficacy of syringaldehyde and the underlined molecular involvement of syringaldehyde in a glucose-lowering effect. The results revealed that syringaldehyde dose-dependently suppressed blood glucose in both the OSTT and OGTT when referenced to acarbose and metformin, respectively. Surprisingly, syringaldehyde triggered jejunum motility (ex vivo) via activation of the muscarinic-type acetylcholine receptor. By performing virtual screening with molecular docking, the data showed that syringaldehyde nicely interacted with glucagon-like peptide 1 receptor (GLP-1R), peroxisome proliferator-activated receptor (PPAR), dipeptidyl peptidase-IV (DPP-4), acetylcholine M2 receptor, and acetylcholinesterase. These results showed that syringaldehyde can potentiate intestinal contractility to abolish the α-amylase reaction when concurrently reducing retention time and glucose absorption to achieve a glucose-lowering effect in diabetic mice, suggesting its potential therapeutic benefits with improvement for use as a prophylactic and treatment.

【 授权许可】

Unknown