The role of diosgenin in crohn’s disease

Clinical Phytoscience

Sunday Ogundepo¹  Janet Olasore¹  Abdullahi Alausa¹  David Adepoju¹  Mercy Olatinwo¹  Kingsley Chijioke Ali²  Adinnu M. Chiamaka³  Matthias Taiwo Aladesanmi⁴  Ugwu Obiora Celestine⁵  Ogochukwu Jennifer Umezinwa⁶ 

[1] Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology;Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria;Department of Food Science and Technology, Micheal Okpara University of Agriculture;Department of Human Nutrition and Dietetics, Faculty of Public Health, University of Ibadan;Department of Pharmacology, Faculty of Pharmaceutical Sciences, Enugu State University of Technology;Pharmacology/ Physiology Unit, Department of Science Laboratory Technology, University of Nigeria;

关键词: Crohn’s disease;    Diosgenin;    Inflammation;    STAT3;    NF-кB activity;   

DOI  :  10.1186/s40816-022-00338-z

来源: DOAJ

【 摘 要 】

Abstract Inflammatory bowel disease (IBD) is a chronic idiopathic inflammation that can grossly affect the entire gastrointestinal tract (GIT) from the mouth to the anus. Crohn’s disease is the most known type of IBD and has been the focus of attention due to its increase in prevalence worldwide. Although the etiology is yet to be elucidated, recent studies have pointed out Crohn’s disease to arise from a complex interaction between environmental influences, genetic predisposition, and altered gut microbiota, resulting in dysregulated adaptive and innate responses. The presenting hallmarks of Crohn’s disease may include weight loss, nausea, vomiting, abdominal pain, diarrhea, fever, or chills. Treatment is usually done with many approved immunosuppressive drugs and surgery. However, a promising avenue from natural compounds is a safer therapy due to its safe natural active ingredients and the strong activity it shows in the treatment and management of diseases. Diosgenin, “a major biologically active natural steroidal sapogenin found in Chinese yam,” has been widely reported as a therapeutic agent in the treatment of various classes of disorders such as hyperlipidemia, inflammation, diabetes, cancer, infection, and immunoregulation. In this review, an analysis of literature data on diosgenin employed as a therapeutic agent for the treatment of Crohn’s disease is approached, to strengthen the scientific database and curtail the dreadful impact of Crohn’s disease.

【 授权许可】

Unknown