Expression of Cyr61 is associated with clinical course in patients with Crohn’s disease

BMC Gastroenterology

Jae Kyun Ju¹  Dong Hyun Kim²  Su-Mi Lee²  Hyun Soo Kim²  Seon-Young Park²  Jin Ook Chung²  Kyung-Hwa Lee³  Jae-Hyuk Lee³ 

[1] Department of General Surgery, Chonnam National University Medical School, Gwangju, South Korea;Department of Internal Medicine, Chonnam National University Medical School, 42, Jaebongro, Dong-ku, 501-757, Gwangju, Korea;Department of Pathology, Chonnam National University Medical School, Gwangju, South Korea;

关键词: Crohn’s disease;    Cyr61;    Inflammation;    Recurrence;   

DOI  :  10.1186/s12876-021-01713-9

来源: Springer

【 摘 要 】

BackgroundsCysteine-rich angiogenic inducer 61 (Cyr61) is emerging as an important regulator of tissue homeostasis and wound repair. We aim to explore the colonic mucosal expression of Cyr61 and analyze the association between Cyr61 expression and clinical course in patients with Crohn’s disease (CD).MethodsEndoscopic samples were identified from 83 CD patients with and 372 controls by searching pathological reports. Among them, age- and sex- matched 43 of each group by a propensity score were selected to compare Cyr61 expression by immunohistochemistry (IHC). IHC scores for Cyr61 expression of CD patients were divided into tertiles to evaluate the association with clinical course. We also measured the level of mRNA for Cyr 61 and proinflammatory genes in inflamed and noninflamed colonic mucosal lesions from CD patients.ResultsThe mean IHC scores for Cyr61 expression was higher in CD patients (86.5) than in controls (46.1, P < 0.001). In CD patients, the mean IHC scores for Cyr61 expression (68.3) was lower in patients with clinical recurrence than in patients without recurrence (92.2, P = 0.01). Cyr61 mRNA levels in inflamed mucosa were twofold higher than those in non-inflamed lesion (P > 0.05) and the mRNA levels of IL-6 and TLR-4 in inflamed mucosa were significantly higher than those in non-inflamed mucosa in CD patients (all P < 0.05). When CD patients were stratified into tertile groups according to IHC scores for Cyr61 expression, clinical recurrence rates tended to be lower in patients with high Cyr61 expression (P for trend = 0.02). Compared with tertile 1 of Cyr61 expression, tertile 3 of Cyr 61 expression was associated with reduced risk of clinical recurrence (OR 0.43, 95% CI 0.20–0.92) after adjustment for age, sex and CD activity index at the time of colonoscopy in CD patients (P = 0.03).ConclusionsCyr61 mucosal expression in CD patients was inversely associated with clinical course. Future study need to be considered to evaluate whether Cyr 61 may play a role in activating inflammatory responses and contributing to wound healing and tissue repair in patients with CD.

【 授权许可】

CC BY