期刊论文详细信息
Viruses
Attach Me If You Can: Murine Norovirus Binds to Commensal Bacteria and Fungi
JasmineL. Madrigal1  Sutonuka Bhar1  NematO. Keyhani1  MelissaK. Jones1  Samantha Hackett1  Haley Engelken1  Ross Joseph1 
[1] Microbiology and Cell Science Department, IFAS, University of Florida, Gainesville, FL 32611, USA;
关键词: norovirus;    murine norovirus;    virus–bacterial interaction;    fungal attachment;   
DOI  :  10.3390/v12070759
来源: DOAJ
【 摘 要 】

The presence of commensal bacteria enhances both acute and persistent infection of murine noroviruses. For several enteric viral pathogens, mechanisms by which these bacteria enhance infection involve direct interactions between the virus and bacteria. While it has been demonstrated that human noroviruses bind to a variety of commensal bacteria, it is not known if this is also true for murine noroviruses. The goal of this study was to characterize interactions between murine noroviruses and commensal bacteria and determine the impact of bacterial growth conditions, incubation temperature and time, on murine norovirus attachment to microbes that comprise the mammalian microbiome. We show that murine noroviruses bind directly to commensal bacteria and show similar patterns of attachment as human norovirus VLPs examined under the same conditions. Furthermore, while binding levels are not impacted by the growth phase of the bacteria, they do change with time and incubation temperature. We also found that murine norovirus can bind to a commensal fungal species, Candida albicans.

【 授权许可】

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