Prevalence of Murine Norovirus Infection in Korean Laboratory Animal Facilities

Journal of Veterinary Medical Science

Tae-Hyun KIM³  Seung Hyeok SEOK³  Ju-Hee HAN³  Doo Hyun CHUNG²  Jae-Hak PARK³  Byeong-Cheol KANG²  Jong Rhan KIM³  Dong Jae KIM³  Min-Won BAEK³  Patricia V. TURNER¹  Yi-Rang NA³ 

[1] Department of Pathology, Ontario Veterinary College, University of Guelph;Biomedical Research Institute, Seoul National University Hospital;Department of Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University

关键词: genetically modified mouse;    Korea;    murine norovirus;    prevalence;   

DOI  :  10.1292/jvms.10-0226

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(9)Cited-By(5)Currently, murine noroviruses (MNV) are the most prevalent viral pathogens identified in laboratory animal facilities. While several reports exist concerning the prevalence of MNV in North American research facilities, very few reports are available for other parts of the world, including Korea. This study evaluated the prevalence of MNV infection in 745 murine sera collected from 15 animal facilities in Korea by enzyme linked immunosorbent assay (ELISA). Positive cases were subcategorized by murine strain/genetics, housing environments and animal sources. In summary, 6.6% of inbred/outbred mice purchased from commercial vendors were seropositive, 9.6% of in-house colonies were seropositive and 27.0% of genetically modified mice (GMM) were seropositive. Partial gene amplification of fecal isolates from infected animals showed that they were homologous (100%) with MNV-4.

【 授权许可】

Unknown