Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases

Neurobiology of Disease

Luís Pereira de Almeida¹  Joana Duarte-Neves²  Cláudia Cavadas² 

[1] Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal;CNC – Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal;

关键词: Neuropeptide Y;    NPY;    NPY receptors;    Neurodegenerative diseases;    Alzheimer's disease;    Parkinson's disease;   

DOI  :  

来源: DOAJ

【 摘 要 】

Neuropeptide Y (NPY) and NPY receptors are widely expressed in the mammalian central nervous system. Studies in both humans and rodent models revealed that brain NPY levels are altered in some neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease and Machado-Joseph disease. In this review, we will focus on the roles of NPY in the pathological mechanisms of these disorders, highlighting NPY as a neuroprotective agent, as a neural stem cell proliferative agent, as an agent that increases trophic support, as a stimulator of autophagy and as an inhibitor of excitotoxicity and neuroinflammation. Moreover, the effect of NPY in some clinical manifestations commonly observed in Alzheimer's disease, Parkinson's disease, Huntington's disease and Machado-Joseph disease, such as depressive symptoms and body weight loss, are also discussed. In conclusion, this review highlights NPY system as a potential therapeutic target in neurodegenerative diseases.

【 授权许可】

Unknown