Quality of life in patients with allergic and immunologic skin diseases: in the eye of the beholder

Clinical and Molecular Allergy

Federica Belluzzo¹  Alessandro Pannofino²  Lucia Guidolin³  Carla Lombardo⁴  Daniele Tarrini⁵  Filippo Fassio⁶  Caterina Foti⁷  Francesca Ambrogio⁷  Domenico Bonamonte⁸  Aurora De Marco⁸  Paola Lucia Minciullo⁹  Eustachio Nettis^1,10  Lorenzo Salvati^1,11  Ester Di Agosta^1,11  Cataldo Patruno^1,12  Maria Passante^1,12  Aikaterini Detoraki^1,13  Maddalena Napolitano^1,14  Alessia Gatta^1,15  Roberta Parente^1,16  Giuseppe Spadaro^1,17  Laura Bonzano^1,18  Luisa Angileri^1,19  Silvia Mariel Ferrucci^1,19  Raffaele Brancaccio^2,20  Oliviero Rossi^2,21  Cristina Quecchia^2,22  Donatella Lamacchia^2,23  Ilaria Baiardini^2,24  Elisabetta Di Leo^2,25  Rosella Gallo^2,26  Natale Schettini^2,27  Monica Corazza^2,27  Adriana Di Guida^2,28  Paolo Custurone^2,29  Fabrizio Guarneri^2,29  Andrea Paravisi^3,30  Katharina Hansel^3,31  Marta Tramontana^3,31  Elettra Antonelli^3,31  Luca Stingeni^3,31  Diego Peroni^3,32  Marta Fantò^3,33 

[1] ASP Trapani;Allergology and Immunology Clinic, Operative Unit of Medicine, Policoro Hospital;Allergy Unit, Department of Medicine, University of Verona;Allergy Unit, Villa Igea Hospital. A.P.S.S. Trento;Allergy and Clinical Immunology Unit, Department of Clinical Medicine, Mauriziano Umberto I Hospital, University of Turin;Allergy and Clinical Immunology Unit, San Giovanni di Dio Hospital;Department of Biomedical Science and Human Oncology, Section of Dermatology, University of Bari;Department of Biomedical Sciences and Human Oncology, Section of Dermatology, University of Bari;Department of Clinical and Experimental Medicine, School and Division of Allergy and Clinical Immunology, University Hospital ‘G. Martino’;Department of Emergency and Organ Transplantation, School and Chair of Allergology and Clinical Immunology, University of Bari - Aldo Moro;Department of Experimental and Clinical Medicine, University of Florence;Department of Health Sciences, University Magna Graecia of Catanzaro;Department of Internal Medicine, Clinical Immunology, Clinical Pathology and Infectious Disease, Azienda Ospedaliera Universitaria Federico II;Department of Medicine and Health Science “V. Tiberio”, University of Molise;Department of Medicine and Science of Ageing, G. d’Annunzio University;Department of Medicine, Division of Allergy and Clinical Immunology, University of Salerno;Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II;Dermatology Unit, Azienda USL – IRCCS di Reggio Emilia;Dermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico;Division of Allergy and Clinical Immunology, “Santa Maria Della Speranza” Hospital;Immunoallergology Unit, SOD Immunoallergologia, Azienda Ospedaliero-Universitaria Careggi;Io e l’Asma Center, Children’s Hospital, ASST Spedali Civili;Personalized Medicine, Asthma and Allergy, IRCCS Humanitas Research Hospital;Respiratory Unit for Continuity of Care, IRCCS Ospedale Policlinico San Martino, Department of Internal Medicine (DiMI), University of Genoa;Section of Allergy and Clinical Immunology, Unit of Internal Medicine-“F. Miulli” Hospital;Section of Dermatology - Department of Health Sciences, University of Genoa, Ospedale Policlinico San Martino - IRCCS;Section of Dermatology and Infectious Diseases, Department of Medical Sciences, University of Ferrara;Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II;Section of Dermatology, Department of Clinical and Experimental Medicine, University of Messina;Section of Dermatology, Department of Health Sciences, University of Genoa, Ospedale Policlinico San Martino - IRCCS;Section of Dermatology, Department of Medicine and Surgery, University of Perugia;Section of Pediatrics, Department of Clinical and Experimental Medicine, University of Pisa;Unit of Allergology, Department of Dermatology, Policlinico Umberto I, Hospital-University Sapienza of Rome;

关键词: Quality of life;    Atopic dermatitis;    Allergic contact dermatitis;    Hereditary angioedema;    Cutaneous mastocytosis;    Urticaria;   

DOI  :  10.1186/s12948-021-00165-6

来源: DOAJ

【 摘 要 】

Abstract Allergic and immunologic skin diseases negatively impact the quality of life (QoL) of affected patients with detrimental consequences. Nonetheless, in everyday clinical practice the evaluation of QoL is often overlooked. Considering the increasing prevalence of atopic dermatitis, allergic contact dermatitis, hereditary angioedema, cutaneous mastocytosis, and urticaria, it is essential to determine the effects of allergic and immunologic skin diseases on QoL. A joint meeting (GET TOGETHER 2021) of the Italian Society of Allergology, Asthma and Clinical Immunology (SIAAIC) and the Italian Society of Allergological, Occupational and Environmental Dermatology (SIDAPA) aimed to summarize the features of the main QoL tools used in these diseases and to describe the extent of QoL impairment as well as the impact of treatments on QoL, particularly biologic therapies. The assessment of QoL in patients with allergic and immunologic skin diseases relies on generic, organ-specific and disease-specific questionnaires. While generic and organ-specific questionnaires allow comparison between different diseases, disease-specific questionnaires are designed and validated for specific cohorts: the QoL Index for Atopic Dermatitis (QoLIAD) and the Childhood Atopic Dermatitis Impact Scale (CADIS) in atopic dermatitis, the ACD-11 in allergic contact dermatitis, the Angioedema QoL Questionnaire (AE-QoL) and the Hereditary Angioedema QoL questionnaire (HAE-QoL) in hereditary angioedema, the Mastocytosis QoL Questionnaires (MCQoL e MQLQ) in cutaneous mastocytosis, and the Chronic Urticaria QoL questionnaire (CU-Q2oL) in urticaria. Among the many factors that variably contribute to QoL impairment, pruritus can represent the leading cause of patient discomfort. Biologic therapies significantly ameliorate QoL in atopic dermatitis, hereditary angioedema, mastocytosis and chronic urticaria. In general, adequate management strategies are essential for improving QoL in patients with allergic and immunologic skin diseases.

【 授权许可】

Unknown