Associations between NIH Toolbox Cognition Battery and in vivo brain amyloid and tau pathology in non‐demented older adults

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

Richard C. Gershon¹  Neelesh K. Nadkarni²  Dana L. Tudorascu²  Beth E. Snitz³  Ann D. Cohen⁴  William E. Klunk⁴  Howard J. Aizenstein⁴  Sandra Weintraub⁵  Zheming Yu⁶  Brian J. Lopresti⁶  Charles M. Laymon⁶  Elizabeth Campbell⁶  Davneet S. Minhas⁶ 

[1] Department of Medical Social Sciences Northwestern University Feinberg School of Medicine Chicago Illinois;Department of Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania;Department of Neurology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania;Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh Pennsylvania;Department of Psychiatry and Behavioral Sciences Northwestern University Feinberg School of Medicine Chicago Illinois;Department of Radiology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania;

关键词: Alzheimer's disease;    biomarkers;    cognition;    neuropsychology;   

DOI  :  10.1002/dad2.12018

来源: DOAJ

【 摘 要 】

Abstract Introduction The National Institutes of Health (NIH) Toolbox Cognition Battery (NIHTB‐CB) was developed to be a common assessment metric across a broad array of research studies. We investigated associations between NIHTB‐CB and brain amyloid and tau deposition in cognitively unimpaired older adults. Methods One hundred eighteen community‐based volunteers completed magnetic resonance imaging (MRI), Pittsburgh compound B (PiB)‐PET (positron emission tomography) and AV‐1451‐PET neuroimaging, a neuropsychological evaluation, NIHTB‐CB, and the Clinical Dementia Rating (CDR) scale. Demographically adjusted regression models evaluated cognition–biomarker associations; standardized effect sizes allowed comparison of association strength across measures. Results No NIHTB‐CB measures were associated with amyloid deposition. NIHTB‐CB measures of fluid cognition, including Pattern Comparison Processing Speed, Dimensional Change Card Sort, and Fluid Cognition Composite, were associated with tau deposition in higher Braak regions. Pattern Comparison Processing Speed was the most robust association with sensitivity analyses. Discussion NIHTB‐CB tasks of processing speed and executive functions may be sensitive to pathologic tau deposition on imaging in normal aging.

【 授权许可】

Unknown