The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis

Microorganisms

Noémie Coron¹  Renaud Prevel¹  Thomas Bazin¹  Michael Fayon¹  Thierry Schaeverbeke¹  Patrick Berger¹  Raphaël Enaud¹  Louise-Eva Vandenborght¹  Laurence Delhaes¹  Thierry Lamireau¹ 

[1] Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, FHU ACRONIM, University Bordeaux,33000 Bordeaux, France;

关键词: brain–gut axis;    mycobiome;    microbiome;    dysbiosis;    neurological disorders;    psychiatric disorders;    fungus;   

DOI  :  10.3390/microorganisms6010022

来源: DOAJ

【 摘 要 】

In recent years, the gut microbiota has been considered as a full-fledged actor of the gut–brain axis, making it possible to take a new step in understanding the pathophysiology of both neurological and psychiatric diseases. However, most of the studies have been devoted to gut bacterial microbiota, forgetting the non-negligible fungal flora. In this review, we expose how the role of the fungal component in the microbiota-gut-brain axis is legitimate, through its interactions with both the host, especially with the immune system, and the gut bacteria. We also discuss published data that already attest to a role of the mycobiome in the microbiota-gut-brain axis, and the impact of fungi on clinical and therapeutic research.

【 授权许可】

Unknown