The Brain–Gut–Microbiome Axis in Psychiatry

International Journal of Molecular Sciences

Won-Myong Bahk¹  YoungSup Woo¹  Seung-Ho Jang²  Sang-Yeol Lee² 

[1] Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul 07345, Korea;Department of Psychiatry, School of Medicine, Wonkwang University, Iksan 54538, Korea;

关键词: brain–gut axis;    microbiome;    psychiatry;    neurotransmitters;   

DOI  :  10.3390/ijms21197122

来源: DOAJ

【 摘 要 】

Beginning with the concept of the brain–gut axis, the importance of the interaction between the brain and the gastrointestinal tract has been extended to the microbiome with increasing clinical applications. With the recent development of various techniques for microbiome analysis, the number of relevant preclinical and clinical studies on animals and human subjects has rapidly increased. Various psychotic symptoms affect the intestinal microbiome through the hypothalamus–pituitary–adrenal gland axis. Conversely, the intestinal microbiome regulates the gastrointestinal tract environment and affects psychological factors by means of the microorganisms or their metabolites, either acting directly on the brain or through the synthesis of various neurotransmitters. This review discusses the clinical applicability of the brain–gut–microbiome axis and directions for improving psychological symptoms based on the studies published to date.

【 授权许可】

Unknown