Application of Metabonomics in Early Diagnosis of Diseases

Journal of International Translational Medicine

Qiao LIU¹ 

[1] Department of Pharmacy, Chenzhou No.1 People's Hospital, Chenzhou, Hunan, 423000, China;

关键词: Metabonomics;    Tumor;    Cardiovascular diseases;    Respiratory diseases;    Early diagnosis;   

DOI  :  10.11910/2227-6394.2015.03.02.13

来源: DOAJ

【 摘 要 】

With the development of life sciences, people have changed their focus from local research to systematic biology, thus contributing to the development of a series of “omics”, including genomics, transcriptomics, proteomics and metabonomics, etc. Metabonomics is a presently developed new branch of science that can provide qualitative and quantitative analysis on all metabolites with low-molecular quality in the body, tissues or cells of an organism. It recognizes the changes and rules of the biological endogenous substance under the impact of internal and external factors by generally and quantitatively detecting multiple small molecular compounds in biological samples, in hope of finding out the metabolic marker clusters in the early stage of diseases so as to provide new pathways for the early diagnosis of the diseases and the realization of individualized drug administration. Additionally, metabonomics research on clinical diseases has become a hot topic and made great achievement in the developmental condition, diagnostic methods, pathogenic mechanism and pharmaceutical efficacy evaluation of diseases. This study mainly reviewed the application and advances of metabonomics in the early diagnosis of malignant tumors, cardiovascular and respiratory diseases, hoping to provide references and prompts for metabonomics-associated researches.

【 授权许可】

Unknown