The Wuhan-Zhuhai (WHZH) cohort study of environmental air particulate matter and the pathogenesis of cardiopulmonary diseases: study design, methods and baseline characteristics of the cohort

BMC Public Health

Jing Yuan³  Weihong Chen³  Tangchun Wu³  Jungang Xie²  Xiaosheng He³  Fan Hou³  Bing Zhang³  Xin Luo³  Zhihong Zhang³  Yanjun Guo³  Yuqing Yang³  Xiuqing Cui³  Yun Zhou³  Huizhen Sun³  Yi Rong³  Aijun Tan¹  Xiaomin Zhang³  Xiji Huang³  Jian Hou³  Yuanchao Song³ 

[1] Zhuhai Center for Disease Control & Prevention, Zhuhai, China;Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Key Laboratory of Environment and Health in Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

关键词: Cardiovascular diseases;    Respiratory diseases;    Pulmonary function;    Particulate matter;    Air pollutants;    Cohort study;   

Others  :  1126678
DOI  :  10.1186/1471-2458-14-994

 received in 2014-07-29, accepted in 2014-09-19,  发布年份 2014

【 摘 要 】

Background

Particulate air pollution has been recognized to be associated with a wide range of adverse health effects, including increased mortality, morbidity, exacerbation of respiratory conditions. However, earlier physiological or pathological changes or long-term bodies’ reaction to air pollutants have not been studied in depth in China. The Wuhan-Zhuhai (WHZH) cohort study is designed to investigate the association between air pollutants exposure and physiological or pathological reactions on respiratory and cardiovascular system.

Methods/Design

The cohort is a community-based prospective study that includes 4812 individuals aged 18–80 years. The collections of data were conducted from April to May 2011 in Wuhan city and in May 2012 in Zhuhai city. At baseline, data on demographic and socioeconomic information, occupational history, family disease history, lifestyle, cooking mode, daily travel mode, physical activity and living condition have been collected by questionnaires. Participants underwent an extensive physical examination, including anthropometry, spirometry, electrocardiography, and measurements of blood pressure, heart rate, exhaled nitric oxide and carbon monoxide. Potential conditions in the lung, heart, liver, spleen, and skin were synchronously performed. In addition, samples of morning urine, fasting blood serum and plasma were collected during physical health examination. DNA were extracted and were stored at -80°C. Environment concentrations of particulate matter and chemicals were determined for 15 days in each of four seasons. Participants are followed for physiological or pathological changes or incidence of cardiopulmonary diseases every 3 years.

Discussion

The results obtained in WHZH cohort study may increase a better understanding of the relationship between particulate air pollution and its components and possible health damages. And the potential mechanisms underlying the development of cardiopulmonary diseases has implications for the development of prevention and treatment strategies.

【 授权许可】

   
2014 Song et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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