Advances of circular RNAs in thyroid cancer: An overview

Biomedicine & Pharmacotherapy

Jing Tao¹  Yi Zhong²  Wei Jiang³  Hanjin Wang³  Guoqiang Sun³  Xiao Li³  Liangliang Wu³  Zhouxiao Li⁴ 

[1] Corresponding authors.;Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China;Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China;Department of General Surgery, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, Jiangsu, China;

关键词: Circular RNA;    Thyroid carcinoma;    Targeted therapy;    Diagnosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Circular RNA (circRNA) is a general term for a type of single-stranded RNAs, they are primarily generated via exon back-splice process in precursor mRNAs (pre-mRNAs). circRNAs refer to an emerging type of endogeneity-correlated closed molecules of RNA in a covalent manner. They mainly function as microRNA sponges, protein brackets, and regulatory element in transcription and splicing process. Recently, it has also starting been noticed that they serve as extraordinary models involved in polypeptides producing process. Although circRNAs have been extensively studied, their function in thyroid carcinoma is still lacking. Thus, we present the latest advances in circRNA research and summarize their fundamental rules of regulating process as well as the mechanism. More importantly, We mainly review the role and mechanism of circRNA in thyroid cancer, which provides an emerging perspective and theoretically supports the treatment of thyroid cancer.

【 授权许可】

Unknown