High urinary interleukin-2 in late post-transplant period portends a risk of decline in kidney allograft function: a preliminary study

BMC Research Notes

Nadiia F. Iefimenko¹  Marina V. Pleten¹  Andriy V. Trailin¹  Tetyana I. Ostapenko²  Olexandr S. Nykonenko² 

[1] Department of Laboratory Diagnostics and General Pathology, State Institution “Zaporizhzhia Medical Academy of Postgraduate Education Ministry of Health of Ukraine”;Department of Transplantology and Endocrine Surgery with the Course of Cardiovascular Surgery, State Institution “Zaporizhzhia Medical Academy of Postgraduate Education Ministry of Health of Ukraine”, Zaporizhzhia Regional Hospital;

关键词: Renal transplantation;    Serum;    Urine;    Interleukins;    GFR;   

DOI  :  10.1186/s13104-017-2936-7

来源: DOAJ

【 摘 要 】

Abstract Background Predictive factors for the rate of decline in kidney allograft function beyond the first post-transplant year have not been thoroughly studied. We aimed to determine whether a single measurement of serum and urinary interleukin 2, interleukin 8 and interleukin 10 at 1–15 years after kidney transplantation could predict a decline in estimated glomerular filtration rate (eGFR) over a 2-year period. Results Greater serum concentrations of interleukin 8 and interleukin 10 in 30 recipients of kidney allograft at enrollment were associated with lower eGFR after 1 year (beta = − 0.616, p = 0.002 and beta = − 0.393, p = 0.035, respectively), whereas serum concentrations of interleukin 8 also demonstrated significant association with eGFR after 2 years of follow-up (beta = − 0.594, p = 0.003). Higher urinary interleukin 2 concentrations were associated with lower eGFR at baseline (rho = − 0.368, p = 0.049) and after the first (beta = − 0.481, p = 0.008) and the second year (beta = − 0.502, p = 0.006) of follow-up. Higher urinary interleukin 2 concentrations predicted certain decline in eGFR of ≥ 25% from baseline after 1 year of follow-up in logistic regression: odds ratio = 2.94, confidence interval 1.06–8.18, p = 0.038. When combined with time after transplantation, urinary interleukin 2 demonstrated good accuracy in predicting rapid decline in eGFR by > −5 mL/min/1.73 m2/year (area under the receiver-operator characteristic curve: 0.855, confidence interval 0.687–1.000, and p = 0.008). Conclusions Our findings suggest that urinary interleukin 2 in the late period after kidney transplantation has promise in identifying patients who are at risk for progressive loss of graft function in a short-time perspective and need closer monitoring.

【 授权许可】

Unknown