Association of IL1 beta gene polymorphism and allograft functions in renal transplant recipients :a case control study from Kashmir Valley

BMC Nephrology

Research Article

Aga Syed Sameer¹  Saniya Nissar²  Zafar A. Shah²  Imtiyaz A. Bhat²  Roohi Rasool²  Mohammad Ashraf Bhat³  Manzoor Ahmad Parry³ 

[1] Department of Basic Medical Sciences, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Makkah Province, Saudi Arabia;Department of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, 190011, Srinagar, Kashmir, India;Department of Nephrology, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India;

关键词: Interleukins;    Renal transplantation;    Allograft;    End stage renal disease;    Kashmir;   

DOI  :  10.1186/s12882-017-0526-5

 received in 2015-08-28, accepted in 2017-03-23,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundCytokines have been found to be the important mediators during renal graft outcome. Therefore, we designed this study to investigate the role of recipients’ IL-1 β promoter (−511) and IL-1 β exon-5 (+3954) polymorphisms with the risk of graft outcome.MethodologyWe enrolled one hundred recipients of living-related renal transplants together with the age and sex matched controls from the healthy population not having any renal abnormality for this study. Genotype frequencies of the IL-1 β promoter (−511) and IL-1 β exon-5 (+3954) were analyzed using PCR-RFLP technique.ResultsOur results revealed significant differences in the healthy control group and patient group in IL 1β +3954 (p < 0.001). The frequency of variant type TT genotype was higher in RE group as compared to SGF and showed 4 fold risk of rejection (OR = 4.54, p < 0.069) although p value was not significant. The frequency of wild type CC genotype and CT was not significant (p value 0.89 and 0.74 respectively).ConclusionOur findings suggest that there is a prevalence of mutated allele of IL-1 gene cluster in our population, which may be responsible for renal dysfunction.

【 授权许可】

CC BY   
© The Author(s). 2017