Soluble dietary fibre partially hydrolysed guar gum markedly impacts on postprandial hyperglycaemia, hyperlipidaemia and incretins metabolic hormones over time in healthy and glucose intolerant subjects

Journal of Functional Foods

Tsutomu Okubo¹  Noriyuki Ishihara²  Mahendra P. Kapoor³ 

[1] Nutrition Division, Taiyo Kagaku Co. Ltd., 1-3 Takaramachi, Yokkaichi, Mie 510 0844, Japan;fax: [phone].;Corresponding author. Nutrition Division, Taiyo Kagaku Co. Ltd., 1-3 Takaramachi, Yokkaichi, Mie 510 0844, Japan. Tel.: [phone];

关键词: Partially hydrolysed guar gum;    Hyperlipidaemia;    Postprandial glycaemia;    Incretins metabolic hormones;   

DOI  :  

来源: DOAJ

【 摘 要 】

Dietary fibre intakes have consistently been associated with reduced risk of diabetes and metabolic syndrome. We investigated in 12 healthy subjects if administration of dietary fibre partially hydrolysed guar gum (PHGG) induces beneficial impact on hyperglycaemia, hyperlipidaemia and incretins metabolic hormones. Administration of 6 g/PHGG with each meal for 12 months significantly lowered the postprandial plasma glucose (PG), reduced both the fasting and postprandial insulin (IRI) and triacylglycerol (TG) levels (p = 0.05). Low-density lipoprotein (LDL) was lower, whereas high-density lipoprotein (HDL) level was significantly increased (p < 0.01). Plasma leptin, high-sensitive C-reactive protein (hs-CRP) and fasting glucagon like peptide (GLP-1) were also lowered. In fact, 3 out of 6 glucose intolerant subjects turned out to be normal glucose tolerant after only 3 months of PHGG supplementation. Therefore, this preliminary study revealed that inclusion of PHGG in diets potentially impact on metabolic health profiles by affecting circulating metabolites that are responsible for glycaemia, hyperinsulinaemia and hyperlipidaemia factors.

【 授权许可】

Unknown