Effects of heparin infusion on plasma lipoproteins in subjects with lipoprotein lipase deficiency

FEBS Letters

Rao, S.N.¹  Cortese, C.¹  Miller, N.E.¹  Lewis, B.¹  Levy, Y.¹ 

[1] Department of Chemical Pathology and Metabolic Disorders, St. Thomas' Hospital Medical School, London SE1 7EH, England

关键词: Lipoproteins;    Hepatic lipase;    Heparin;    Hyperlipidaemia;    Lipoprotein lipase;    High-density lipoprotein;   

DOI  :  10.1016/0014-5793(82)81345-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The role of heparin-releasable hepatic endothelial lipase (HL) in human plasma lipoprotein metabolism was investigated by examining the effects of intravenous infusion of heparin (180 units/kg over 2 h) in 8 subjects with primary extrahepatic lipoprotein lipase deficiency. In addition to reducing the triglyceride concentration in very low-density lipoproteins, heparin-induced release of HL reduced the phopholipid and protein concentrations in the HDL₂ subclass of high-density lipoprotein (by 28% and 36% respectively, mean values) and simultaneously increased the HDL₃ phospholipid concentration (by 23%), providing the first in vivo evidence for a function of HL in the interconversion of the major HDL subfractions in man.

【 授权许可】

Unknown