Apolipoprotein B-Containing Lipoprotein Particle Assembly: Lipid Capacity of the Nascent Lipoprotein Particle.

Manchekar, M. ; Forte, T. M. ; Datta, G. ; Richardson, P. E. ; Segrest, J. P.

Technical Information Center Oak Ridge Tennessee

关键词: Lipoproteins;    Apolipoprotein B;    Submicroscopic particles;    Aqueous environments;    apoB lipid pocket;   

RP-ID  :  DE2005836379

学科分类：工程和技术（综合）

美国|英语

来源: National Technical Reports Library

【 摘 要 】

Plasma lipoproteins are submicroscopic particles composed of lipid and protein held together by noncovalent forces. Their general structure is that of a spheroidal microemulsion formed from an outer layer of phospholipids, unesterified cholesterol, and proteins, with a core of neutral lipids, predominantly cholesteryl ester and triacylglycerols (TAG). Although the microemulsion is the basic structural motif of lipoproteins, several different lipoprotein classes exist that differ in relative amount of lipids, in the protein/lipid ratio, and in the protein species present, resulting in differences in size, density, and electrophoretic mobility. Lipoproteins are generally classified by density, size, and/or protein composition. Apolipoproteins (apo) are amphipathic in nature, in that they have both hydrophobic and hydrophilic regions, and can, therefore, interact with both the lipids of the lipoproteins and with the aqueous environment. Because of the nature of these amphipathic regions, apolipoproteins act as detergents, and have a major role in determining and stabilizing the size and structure of lipoprotein particles.