Optical to Planar X-ray Mouse Image Mapping in Preclinical Nuclear Medicine Using Conditional Adversarial Networks

Journal of Imaging

Irinaios Pilatis¹  George Loudos¹  Christina-Anna Gatsiou¹  Vasilis Eleftheriadis¹  Sophia Sarpaki¹  Maritina Rouchota²  Eleftherios Fysikopoulos²  Spiros Kostopoulos²  Dimitrios Glotsos² 

[1] BIOEMTECH, Lefkippos Attica Technology Park, N.C.S.R. Democritos, 15343 Athens, Greece;Biomedical Engineering Department, University of West Attica, 12210 Athens, Greece;

关键词: molecular preclinical imaging;    image-to-image translation;    PET;    SPECT;    deep learning;    pix2pix;   

DOI  :  10.3390/jimaging7120262

来源: DOAJ

【 摘 要 】

In the current work, a pix2pix conditional generative adversarial network has been evaluated as a potential solution for generating adequately accurate synthesized morphological X-ray images by translating standard photographic images of mice. Such an approach will benefit 2D functional molecular imaging techniques, such as planar radioisotope and/or fluorescence/bioluminescence imaging, by providing high-resolution information for anatomical mapping, but not for diagnosis, using conventional photographic sensors. Planar functional imaging offers an efficient alternative to biodistribution ex vivo studies and/or 3D high-end molecular imaging systems since it can be effectively used to track new tracers and study the accumulation from zero point in time post-injection. The superimposition of functional information with an artificially produced X-ray image may enhance overall image information in such systems without added complexity and cost. The network has been trained in 700 input (photography)/ground truth (X-ray) paired mouse images and evaluated using a test dataset composed of 80 photographic images and 80 ground truth X-ray images. Performance metrics such as peak signal-to-noise ratio (PSNR), structural similarity index measure (SSIM) and Fréchet inception distance (FID) were used to quantitatively evaluate the proposed approach in the acquired dataset.

【 授权许可】

Unknown