Circular RNAs and glioblastoma multiforme: focus on molecular mechanisms

Cell Communication and Signaling

Raziyeh Salami¹  Marziyeh Salami²  Alireza Mafi³  Omid Vakili³  Zatollah Asemi⁴ 

[1] Department of Clinical Biochemistry, School of Medicine, Hamedan University of Medical Sciences;Department of Clinical Biochemistry, School of Medicine, Shahid Sadoughi University of Medical Sciences;Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences;Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences;

关键词: Glioblastoma multiforme;    Circular RNA;    Signaling pathways;    Diagnosis;    Treatment;   

DOI  :  10.1186/s12964-021-00809-9

来源: DOAJ

【 摘 要 】

Abstract Glioblastoma multiforme (GBM), as a deadly and almost incurable brain cancer, is the most invasive form of CNS tumors that affects both children and adult population. It accounts for approximately half of all primary brain tumors. Despite the remarkable advances in neurosurgery, radiotherapy, and chemotherapeutic approaches, cell heterogeneity and numerous genetic alterations in cell cycle control, cell growth, apoptosis, and cell invasion, result in an undesirable resistance to therapeutic strategies; thereby, the median survival duration for GBM patients is unfortunately still less than two years. Identifying new therapeutics and employing the combination therapies may be considered as wonderful strategies against the GBM. In this regard, circular RNAs (circRNAs), as tumor inhibiting and/or stimulating RNA molecules, can regulate the cancer-developing processes, including cell proliferation, cell apoptosis, invasion, and chemoresistance. Hereupon, these molecules have been introduced as potentially effective therapeutic targets to defeat GBM. The current study aims to investigate the fundamental molecular and cellular mechanisms in association with circRNAs involved in GBM pathogenesis. Among multiple mechanisms, the PI3K/Akt/mTOR, Wnt/β-catenin, and MAPK signaling, angiogenic processes, and metastatic pathways will be thoroughly discussed to provide a comprehensive understanding of the role of circRNAs in pathophysiology of GBM. Video Abstract

【 授权许可】

Unknown