Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish

Frontiers in Pharmacology

Giancarlo eBruni¹  Parth eLakhani¹  David eKokel¹ 

[1] Massachusetts General Hospital and Harvard Medical School;

关键词: Zebrafish;    screening;    Phenomics;    Behavior Based Drug discovery;    antipsycotics;   

DOI  :  10.3389/fphar.2014.00153

来源: DOAJ

【 摘 要 】

Most neuroactive drugs were discovered through unexpected behavioral observations.Systematic behavioral screening is inefficient in most model organisms.But, automated technologies are enabling a new phase of discovery-based research in central nervous system (CNS) pharmacology.Researchers are using large-scale behavior based chemical screens in zebrafish to discover compounds with new structures, targets and functions.These compounds are powerful tools for understanding CNS signaling pathways.Substantial differences between human and zebrafish biology will make it difficult to translate these discoveries to clinical medicine. However, given the molecular genetic similarities between humans and zebrafish, it is likely that some of these compounds will have translational utility.We predict that the greatest new successes in CNS drug discovery will leverage many model systems, including in vitro assays, cells, rodents, and zebrafish.

【 授权许可】

Unknown