Glycemic variability is associated with subclinical atherosclerosis in Chinese type 2 diabetic patients

Cardiovascular Diabetology

关键词: Glycemic variability;    Type 2 diabetes;    Atherosclerosis;    Intima-media thickness;    Magnetic resonance angiography.;   

DOI  :  10.1186/1475-2840-12-15

来源: DOAJ

【 摘 要 】

Abstract

Background

The contribution of glycemic variability to macrovascular complications remains unclear. We therefore investigated the association between glycemic variability and cervical and/or intracranial atherosclerosis in Chinese type 2 diabetic patients.

Methods

We conducted a cross-sectional study in 216 type 2 diabetic patients with a hemoglobin A_1c of 8.3 ± 1.7% and a median diabetes duration of 9.0 years. The standard deviation of blood glucose values (SDBG) and the mean amplitude of glycemic excursion (MAGE) were calculated from continuous glucose monitoring system data for assessing glycemic variability while 24h mean blood glucose (MBG) was calculated for measuring overall blood glucose level. Magnetic resonance angiography (MRA) was used to detect cervical and/or intracranial plaque, and ultrasonography was used to quantify carotid intima-media thickness (IMT) as an index of subclinical atherosclerosis.

Results

One hundred and fifty-three patients (70.8%) presented with cervical and/or intracranial lesions on MRA among 216 patients in the study. Elder age, increased systolic blood pressure, increased MBG and elevated low density lipoprotein cholesterol were independent contributors to plaque formation. In patients without stenosis (n = 63), SDBG (r = 0.412, P = 0.001) and MAGE (r = 0.365, P = 0.005) were both correlated with carotid IMT and these relationships remained significant in multiple linear regression analysis (multiple R² = 0.314 for the model including SDBG and multiple R² = 0.268 for the model including MAGE). However, SDBG and MAGE were not significantly different among patients with different stenosis degrees.

Conclusions

Glycemic variability is associated with subclinical atherosclerosis in Chinese type 2 diabetic patients.

【 授权许可】

Unknown