Brain Microdialysate Monoamines in Relation to Circadian Rhythms, Sleep, and Sleep Deprivation – a Systematic Review, Network Meta-analysis, and New Primary Data

Journal of Circadian Rhythms

E. J. Marijke Achterberg¹  Maurice Dematteis²  Cathalijn H. C. Leenaars³  W. H. (Pim) Drinkenburg⁴  Christ Nolten⁴  Matthijs G. P. Feenstra⁵  Ruud N. J. M. A. Joosten⁵  Julia M. L. Menon⁶ 

[1] Department of Animals in Science and Society – Human-Animal Relationship, Utrecht University, Utrecht;Grenobles Alpes University Hospital and Grenoble Alpes University, Faculty of Medicine;Institute for Laboratory Animal Science, Hannover Medical School, Hannover;Janssen Research and Development, a division of Janssen Pharmaceutica N.V, Beerse;Netherlands Institute for Neuroscience (NIN), An Institute of the Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105BA Amsterdam;Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen;

关键词: Systematic review;    network meta-analysis;    microdialysis;    monoamines;    circadian rhythm;    sleep deprivation;   

DOI  :  10.5334/jcr.174

来源: DOAJ

【 摘 要 】

Disruption of the monoaminergic system, e.g. by sleep deprivation (SD), seems to promote certain diseases. Assessment of monoamine levels over the circadian cycle, during different sleep stages and during SD is instrumental to understand the molecular dynamics during and after SD. To provide a complete overview of all available evidence, we performed a systematic review. A comprehensive search was performed for microdialysis and certain monoamines (dopamine, serotonin, noradrenaline, adrenaline), certain monoamine metabolites (3,4-dihydroxyphenylacetic acid (DOPAC), 5-hydroxyindoleacetic acid (5-HIAA)) and a precursor (5-hydroxytryptophan (5-HTP)) in PubMed and EMBASE. After screening of the search results by two independent reviewers, 94 publications were included. All results were tabulated and described qualitatively. Network-meta analyses (NMAs) were performed to compare noradrenaline and serotonin concentrations between sleep stages. We further present experimental monoamine data from the medial prefrontal cortical (mPFC). Monoamine levels varied with brain region and circadian cycle. During sleep, monoamine levels generally decreased compared to wake. These qualitative observations were supported by the NMAs: noradrenaline and serotonin levels decreased from wakefulness to slow wave sleep and decreased further during Rapid Eye Movement sleep. In contrast, monoamine levels generally increased during SD, and sometimes remained high even during subsequent recovery. Decreases during or after SD were only reported for serotonin. In our experiment, SD did not affect any of the mPFC monoamine levels. Concluding, monoamine levels vary over the light-dark cycle and between sleep stages. SD modifies the patterns, with effects sometimes lasting beyond the SD period.

【 授权许可】

Unknown