Designing the Surface Chemistry of Inorganic Nanocrystals for Cancer Imaging and Therapy

Cancers

Thomas Pons¹  Yuzhou Pu¹  Nicolas Lequeux¹  Fanny Delille¹ 

[1] Laboratoire de Physique et d’Etude des Matériaux, Ecole Supérieure de Physique et Chimie Industrielle, Université PSL (Paris Sciences & Lettres), Centre National de Recherche Scientifique, 75005 Paris, France;

关键词: nanoparticle;    gold;    iron oxide;    quantum dot;    surface chemistry;    cancer imaging;   

DOI  :  10.3390/cancers14102456

来源: DOAJ

【 摘 要 】

Inorganic nanocrystals, such as gold, iron oxide and semiconductor quantum dots, offer promising prospects for cancer diagnostics, imaging and therapy, due to their specific plasmonic, magnetic or fluorescent properties. The organic coating, or surface ligands, of these nanoparticles ensures their colloidal stability in complex biological fluids and enables their functionalization with targeting functions. It also controls the interactions of the nanoparticle with biomolecules in their environment. It therefore plays a crucial role in determining nanoparticle biodistribution and, ultimately, the imaging or therapeutic efficiency. This review summarizes the various strategies used to develop optimal surface chemistries for the in vivo preclinical and clinical application of inorganic nanocrystals. It discusses the current understanding of the influence of the nanoparticle surface chemistry on its colloidal stability, interaction with proteins, biodistribution and tumor uptake, and the requirements to develop an optimal surface chemistry.

【 授权许可】

Unknown