Long Non-Coding RNA: A Potential Strategy for the Diagnosis and Treatment of Colorectal Cancer

Frontiers in Oncology

Shanshan Chen¹  Shuo Zhang¹  Beihui He¹  Lingyu Sun²  Yi Fang²  Ruonan He² 

[1] The First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China;The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China;

关键词: long non-coding RNA;    colorectal cancer;    drug resistance;    proliferation;    metastasis;    occurrence;   

DOI  :  10.3389/fonc.2021.762752

来源: DOAJ

【 摘 要 】

Colorectal cancer (CRC), being one of the most commonly diagnosed cancers worldwide, endangers human health. Because the pathological mechanism of CRC is not fully understood, there are many challenges in the prevention, diagnosis, and treatment of this disease. Long non-coding RNAs (lncRNAs) have recently drawn great attention for their potential roles in the different stages of CRC formation, invasion, and progression, including regulation of molecular signaling pathways, apoptosis, autophagy, angiogenesis, tumor metabolism, immunological responses, cell cycle, and epithelial-mesenchymal transition (EMT). This review aims to discuss the potential mechanisms of several oncogenic lncRNAs, as well as several suppressor lncRNAs, in CRC occurrence and development to aid in the discovery of new methods for CRC diagnosis, treatment, and prognosis assessment.

【 授权许可】

Unknown