Involvement of long non-coding RNAs in the progression of esophageal cancer

Cancer Communications

article

Wenhua Xue¹  Quancheng Kan¹  Yuanyuan Zheng¹  Zhibo Shen¹  Lifeng Li⁵  Zhirui Fan⁵  Wenbin Wang¹  Zijia Zhu¹  Yunkai Zhai⁴  Jie Zhao¹ 

[1] Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University;Henan Key Laboratory of Precision Clinical Pharmacy, Zhengzhou University;These authors contributed equally to this work.;Internet Medical and System Applications of National Engineering Laboratory;Department of Oncology, the First Affiliated Hospital of Zhengzhou University

关键词: apoptosis;    biomarker;    diagnosis;    drug resistance;    esophageal cancer;    long non-coding RNA;    metastasis;    prognosis;    proliferation;   

DOI  :  10.1002/cac2.12146

学科分类：社会科学、人文和艺术（综合）

来源: Springer

【 摘 要 】

Esophageal cancer (EC) is one of the most common malignant tumors of the digestive system with high incidence and mortality rate worldwide. Therefore, exploring the pathogenesis of EC and searching for new targeted therapies are the current research hotspot for EC treatment. Long non-coding RNAs (lncRNAs) are endogenous RNAs with more than 200 nucleotides, but without protein-coding function. In recent years, lncRNAs have gradually become the focuses in the field of non-coding RNA. Some lncRNAs have been proved to be closely related to the pathogenesis of EC. Many lncRNAs are abnormally expressed in EC and participate in many biological processes including cell proliferation, apoptosis, and metastasis by inhibiting or promoting target gene expression. LncRNAs can also regulate the progression of EC through epithelial-mesenchymal transformation (EMT), which is closely related to the occurrence, development, and prognosis of EC. In this article, we review and discuss the involvement of lncRNAs in the progression of EC.

【 授权许可】

CC BY|CC BY-NC-ND