Enhanced bioavailability and relative distribution of free (unconjugated) curcuminoids following the oral administration of a food-grade formulation with fenugreek dietary fibre: A randomised double-blind crossover study

Journal of Functional Foods

Della Jacob¹  Veera Konda¹  Ramadassan Kuttan¹  Balu Maliakel²  Johannah NM²  Dinesh Kumar²  Krishnakumar IM³  Subash PS⁴  Abhilash Maliakkal⁴ 

[1] Aromatics Pvt Ltd, Malayidamthuruthu PO, Cochin, 683561, India;;Akay Flavours &Amala Cancer Research Centre, Amala Nagar PO, Trichur, 680555, India;SMO Connect Clinical Research Services Pvt Ltd, D&N Space, Cochin, 682022, India;

关键词: Curcumin;    Curcuminglucuronide;    Conjugated curcumin metabolites;    Bioavailability;    Pharmacokinetics;    Oral administration;   

DOI  :  

来源: DOAJ

【 摘 要 】

Despite the various reports on enhanced bioavailable formulations of curcumin, systemic oral bioavailability of unconjugated curcuminoids remains a challenge. Considering the differences in plasma bioactivity and membrane permeability of free curcuminoids over conjugated metabolites, herein we report a randomised double-blinded crossover study (n = 50) to investigate the relative bioavailability and pharmacokinetics of free curcuminoids following the oral administration of high (1000 mg) and low (250 mg) doses of a food-grade formulation of curcumin with fenugreek dietary fibre as curcumagalactomannosides (CGM), which was reported to exhibit improved blood-brain – barrier permeability in rats. CGM administration provided over 45.5-fold enhancement in free curcuminoids bioavailability with improved pharmacokinetics when compared to unformulated standard curcumin. Further investigations with and without enzymatic hydrolysis of plasma collected over 5 h post-administration of CGM at 1000 mg dose revealed higher free curcuminoids in plasma (74 ± 8%) as compared to conjugated curcuminoids (26 ± 12%) indicating a significant distribution of free curcuminoids over conjugated curcumin metabolites.

【 授权许可】

Unknown